DNA Sequencing

Abstract

The sequencing of the Human Reference Genome, with Human Genome Project announced ten years ago, provided a roadmap that is the foundation for modern biomedical research. Reference Genome represents digital database founded by scientists which contains representative examples of species genomes. The need for sequencing has never been greater than it is today. Sequencing has found its applications within diverse research sectors including comparative genomics and evolution, forensics, epidemiology, and applied medicine for diagnostics and therapeutics. Arguably, the strongest rationale for ongoing sequencing is the question for identification and interpretation of human sequence variation as it relates to health and disease. The paper gives review of current DNA sequencing algorithms and techniques as well as next-generation of DNA sequencing. Since the DNA sequencing field is changing rapidly the information in this paper represent a snapshot of this particular moment.