Structural Bioinformatics Analysis On Diabetes Associated Proteins

Abstract

The Human Diabetes Proteome Project (HDPP) mentioned more than 1000 diabetes associated proteins. 400 diabetes associated proteins whose structure is not analyzed yet are selected from the database. Each proteins structure is analyzed via prediction tools in order to reveal structural similarity with IAPP (Islet Amyloid Polypeptide) whose role is well characterized in diabetes. Through similarity analysis between proteins and in region of disulfide bridge formation, we aimed to find similar possible misfolding patterns in other diabetes associated proteins. Result indicates that Calcitonin Gene Related Peptide I is the only proteins who shows high structural and conformational similarity with IAPP. We believe that one of the possible enrolments of the protein Calcitonin Gene Related Peptide 1 to the diabetes can be similar conformational changes due to disulfide bridge formation break. Finally we propose that the accumulation of misfolded Calcitonin Gene Related Peptide 1 is similar to other protein based conformational diseases. Further structural analyses needs to be performed to confirm these results.